81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Prof. Haass started to work on Alzheimer's disease (AD) in 1990 at a time, when very little was known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion hinein this field that Aß may be produced from its precursor hinein a physiologically gewöhnlich pathway and not necessarily in a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved hinein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production in patients.
You can do following driving classes with us. Click on each class to get more information. Class B
The practical side is taken care of in our top-notch driving-school vehicles, each equipped with a double-pedal Gebilde. If requested, we can also provide you with tuition in an automatic car at our driving school in Munich.
Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass was the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which welches overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He was also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved rein brain development (such as myelination and cell differentiation) but also provided the Stützpunkt for several current therapeutic approaches.
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We are the new, modern Munich driving school for Schwabing and Maxvorstadt. On three evenings a week, ur fully-equipped driving school will give you the opportunity to become familiar with the theory – quickly and thoroughly.
We are using interdisciplinary approaches ranging from biophysics, biochemistry and cellular and molecular biology to rein vivo models and life imaging.
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Next to the Ostfriedhof bus and tram stop Can I take a trial lesson rein the theoretical course in order to get an impression of the atmosphere?
Was ich am günstigsten fand güter die Fahrstunden mit Joachim, wirklich ein toller Fahrlehrer bei dem du wirklich Dasjenige Gefühl bekommst das es ihn spaß macht dir das alles beizubringen. Wurde es ans herz legen An dieser stelle dein copyright zu machen ansonsten sobald es m…
If you have already acquired a copyright in a different country, our team will help you with transferring it and will advise you on your way to obtaining a German driving permit.
Where can I find an economical first-aid course? We also offer courses daily hinein the Munich city area. They are all held hinein classrooms adjacent to U/S-Bahn stations. Moosach
Leichte vierrädrige Straßen-Quads mit einer Nenndauerleistung/Nutzleistung von nicht eine größere anzahl denn Hier 4 kW des weiteren vierrädrige Leichtkraftfahrzeuge mit einer Nenndauerleistung/Nutzleistung von nicht eine größere anzahl denn 6 kW, jeweilig mit nicht eine größere anzahl denn beide Sitzplätzen, einer durch die Bauart bestimmten Höchstgeschwindigkeit von nicht eine größere anzahl denn 45 stundenkilometer, einer maximalen Leermasse von 425 kg und einem Fremdzündungsmotor mit einem Hubraum von nicht eine größere anzahl wie 50 cm³ oder einem Selbstzündungsmotor mit einem Hubraum von nicht mehr denn 500 zentimeter³ oder einer anderen Antriebsform.
Our learning-Durchschuss check helps you to learn how to learn more efficiently. Success may be improved in a short time.
You want to get your driving licence hinein Munich as soon as possible, in an enjoyable and straightforward way? If so, you’ve come to exactly the right place! We are a Munich driving school and guarantee you all-round support hinein theory, practice and other aspects of Schulung.